Home > The importance of prebiotics in the first 1,000 days for gut and health immunity

The importance of prebiotics in the first 1,000 days for gut and health immunity

Nutrition in the first 1,000 days of life has long-term impact. The first 1,000 days (from conception to age two) are widely accepted to be the most significant period in a child’s development2,3. During this formative time, a child’s organs and body systems grow rapidly and are highly responsive to nutritional influence4. Therefore, this period offers a critical window to influence long-term health.

 

Know your biotics1

  • Probiotics are naturally occurring friendly bacteria that affect the gut microbiota when ingested
  • Prebiotics are non-digestible carbohydrates that pass intact through the upper part of the gut and stimulate the growth or activity of friendly bacteria
  • Postbiotics are bioactive components produced by the metabolic activity of probiotic bacteria, which have an important role in the regulation of biologic activity in the gut
Figure 1

 

Building immunity from the start

The gut and immune system develop rapidly throughout the first 1,000 days, as babies move from a protected environment to one where they are exposed to lots of immune challenges. Nutrition plays a significant role in influencing the gut microbiota, shaping the development of both the gut and the immune system5. From birth, microbes in the gut perform essential duties6:

  • The digestion and metabolism of food
  • The production of neurotransmitters that affect behaviour and cognitive function. The gut microbiota exerts influence over anxiety, mood, sociability and cognition
  • The development and activation of the immune system. The gut is the centre of the immune system – 70-80% of the body’s immune cells are in the gut7

Supporting the maturation, diversity and condition of the gut microbiota through optimal nutrition in the first 1,000 days is fundamental for the development of a healthy immune system8,9, protecting against harmful bacteria, reducing risk of disease, and safeguarding future health5.

 

Prebiotic power

Breastmilk is the best form of nutrition for babies, containing all of the nutrients required to support a baby’s healthy growth and development in the first six months (see figure 110,11).

In early infancy, nutrition greatly influences the composition of the gut microbiota, and in turn, the emerging immune system5,12,13. The composition of breastmilk is complex; it helps to strengthen baby’s developing immune system by providing protective bioactive elements such as prebiotic oligosaccharides, live bacteria and metabolites14,15. These prebiotic oligosaccharides help to positively shape the infant’s gut microbiota, promoting the growth of beneficial or ‘friendly’ bacteria (e.g: bifidobacteria and lactobacilli)8,16-18.

Prebiotics are non-digestible carbohydrates. They travel to the gut intact and are fermented by the friendly bacteria that reside there18. Postbiotics are produced by this natural fermentation process in the gut, including short-chain fatty acids (SCFAs)19, which help to maintain the gut barrier and have been shown to influence immune function5.

 

Pioneering prebiotic research

Inspired by over 40 years of breastmilk research, Nutricia Early Life Nutrition was the first company to introduce a blend of short-chain prebiotic galacto-oligosaccharides and long-chain fructo-oligosaccharides (scGOS/lcFOS) into infant formula. Like naturally occurring prebiotic oligosaccharides in breastmilk, the scGOS/lcFOS (9:1) prebiotic mixture are not digested by the infant’s digestive enzymes and instead selectively stimulates growth and activity of friendly bacteria in the gut16,20.

Nutricia Research has conducted more than 30 clinical studies to evaluate the benefits of scGOS/lcFOS (9:1). These studies have shown that the addition of this unique prebiotic mixture stimulates a bifidogenic gut microbiota21, closer to the composition found in breastfed babies, to support the development of a healthy immune system16,18,22, and brings stool consistency and defaecation frequency closer to those of breastfed infants18,23,24.

 

Benefits for baby of prebiotics in infant formula

The prebiotic mixture scGOS/lcFOS (9:1) has been proven to:

  • Increase levels of friendly gut bacteria and reduce levels of potentially harmful bacteria16,22,25,26
  • Improve stool frequency and consistency18,23,24
  • Reduce occurrence of infections requiring antibiotics (Figure 2)20,27
  • Reduce incidence of allergic symptoms, such as atopic dermatitis27,28
Figure 2: Reduced occurrence of infections in the first two years of life27

 

Supporting immunity from the start

Immunity-boosting, naturally occurring prebiotics in breastmilk are just one of the many incredible ways in which breastmilk offers infants the very best start in life. In early infancy, babies are dependent on milk as the sole form of nutrition, and it is important that all nutritional needs are met, which is why the World Health Organization recommends exclusive breastfeeding for the first six months of a baby’s life29.

Nutricia Early Life Nutrition is at the forefront of breastmilk research, committed to increasing the understanding of its unique composition, power and influence on early life development. Because of this pioneering research, babies who are combination-fed, or who receive formula exclusively, can continue to benefit from innovations such as prebiotics to promote the development of a healthy and diverse gut microbiota.

For more information on probiotics and how they support the development of baby’s gut microbiota for immunity, visit www.eln.nutricia.co.uk. If you would like to find out more about Nutricia’s products and innovations visit the website or contact the Nutricia healthcare professional helpline: 0800 996 1234 (open from 8am to 8pm, Monday to Friday).

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